The Janet H. and C. Harry Knowles Foundation was established in 1999 to strengthen the quality of science and mathematics teachers teaching in grades 9-12 in United States schools. The Knowles Science Teaching Foundation supports individuals and programs designed to encourage and sustain young scientists and mathematicians as they dedicate their lives to teaching other young people and to becoming leaders in the field of education. The Foundation also supports efforts that provide insight into how to best prepare high school science and mathematics teachers.

The Knowles established the foundation in recognition of the importance of quality science and mathematics instruction to the well-being and future of our country as well as in appreciation of the many dedicated science and mathematics teachers that helped form their lives.